Clinician's Guide to HIV and Hepatitis Guide Update: Entecavir has anti-HIV activity and can select for resistant variants of HIV The Department of Health and Human Services has updated the Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents to recommend that entecavir not be used to treat HBV in HIV/HBV co-infected individuals, unless they are receiving treatment for HIV as well. This update is a result of a case series that revealed entecavir’s anti-HIV activity and ability to select for M184V mutations in HIV. This information updates the information in “Table 5: HBV Treatment Options”, “Table 6: HBV and HIV Treatment Considerations” and in the section entitled “HIV/HBV Co-infection Treatment Considerations” in the Clinician’s Guide to HIV & Hepatitis, January 2007. Please see the resources listed below for more information.
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Sources Department of Health and Human Services. (April 30, 2007). Supplement to the Guidelines of the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Available: http://AIDSinfo.nih.gov. Additional Resources Koziel, M.J., & Peters, M.G. (2007). Viral hepatitis and HIV infection. The New England Journal of Medicine, 356, 1445-1454.
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Hepatitis Toolkit for the Primary Care Provider
Includes algorithms for screening and management, and helpful advice for patients undergoing treatment.
Prepared by the AETC NRC Primary Care Management for the HIV/AIDS Provider Workgroup, Florida/Caribbean AETC; Mountain-Plains AETC; Delta Region AETC and AETC National Resource Center
Authors: Ronald Wilcox, MD; Suzanne Jed, RN and Susa Coffey, MD
HEP C: Inside and Out
A 14-minute educational video that provides an overview of this important public health problem. Through testimonies from those living with HCV and health care providers, the video provides a compelling overview of HCV infection. Targeted to people incarcerated in jails, prisons, and community corrections programs, as well as staff members in those facilities, the primary goal is to raise awareness of the disease. To order visit: www.awarenessalliance.org.
Prepared in 2005 by Mountain Plains AETC; Hep C Connection; Center for Research Strategies and Little Voice
The following tools are available from the AETC National Resource Center:
(under hepatitis coinfection > videos)
- Communicable Diseases: Are You at Risk? A Videotape Initiative to Increase Inmate Testing of HIV, Hepatitis B and C and Sexually Transmitted Diseases
Date: 12/2004
Source: New York/New Jersey AETC
- Caring Inside The Wall: HIV Treatment in the Correctional Setting
Date: 2001
Source: Northwest AETC - Management of HIV/Hepatitis C Co-Infection: A Roundtable
Date: 2005
Source: Northwest AETC
Clinical Manual for Management of the HIV-Infected Adult, 2006 Edition
Hepatitis B Infection Chapter
Hepatitis C Infection Chapter
AIDSinfo - A service of the U.S. Department of Health and Human Services that provides information about federally approved treatment guidelines for HIV and AIDS and opportunistic infections.
Care of Patients Coinfected with HIV-HCV: New Consensus Guidelines from an International Panel
Guidelines for Laboratory Testing and Result Reporting of Antibody to Hepatitis C Virus